sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate

Base Information

• Chemical Name: sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate
• CAS No.: 327183-85-7
• Molecular Formula: C₁₅H₁₂FO₄S*Na
• Molecular Weight: 330.312
• Mol file: 327183-85-7.mol

Synonyms:sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate

Chemical Property of sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate

There total 2 articles about sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluorochalcone (1608-51-1,22966-07-0,102692-46-6) → sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate (327183-85-7)

Guidance literature:

With sodium hydrogensulfite; triethylamine; In methanol; water; toluene; at 0 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2019.03.065

Reference yield:

→ sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate (327183-85-7)

Guidance literature:

Reference yield:

sodium 1-(4-fluorophenyl)-3-oxo-3-phenylpropane-1-sulfonate (327183-85-7) → sodium 1-(4-fluorophenyl)-3-hydroxy-3-phenylpropane-1-sulfonate + sodium 1-(4-fluorophenyl)-3-hydroxy-3-phenylpropane-1-sulfonate

Guidance literature:

With sodium tetrahydroborate; sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h; Overall yield = 92 %; diastereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.03.065

upstream raw materials:

4-fluorochalcone