(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

Base Information

Chemical Name:(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol
CAS No.:131619-23-3
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:

Synonyms:(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

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Chemical Property of (S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

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Technology Process of (S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

There total 4 articles about (S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 131619-19-7
(S)-1-phenyl-2-hydroxyethyl 5,6-dihydro-4-methyl-2H-pyran-2-yl ether

: 131619-23-3
(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

: 131619-21-1
(S)-1-phenyl-2-hydroxyethyl (2R,3R,4R)-3,4-epoxy-4-methyltetrahydropyran-2-yl ether

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 18h;
DOI:10.1021/jo00002a079

Reference yield:

: 131619-14-2
4-Methyl-3,4-dihydro-2H-pyran-4-ol

: 131619-23-3
(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

2: 35 percent / iodinium bis-collidine perchlorate / CH₂Cl₂ / 1 h / 0 °C

3: 97 percent / LiAlH₄ / tetrahydrofuran / 0 °C

4: 7 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / 0 °C

With lithium aluminium tetrahydride; iodonium(di-γ-collidine) perchlorate; pyridinium p-toluenesulfonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00002a079

Reference yield:

: 131619-15-3
4-penten-1-yl 5,6-dihydro-4-methyl-2H-pyran-2-yl ether

: 131619-23-3
(S)-2-((1S,2R,6S)-6-Methyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / iodinium bis-collidine perchlorate / CH₂Cl₂ / 1 h / 0 °C

2: 97 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 7 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / 0 °C

With lithium aluminium tetrahydride; iodonium(di-γ-collidine) perchlorate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00002a079