methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate

Base Information

• Chemical Name: methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate
• CAS No.: 1093868-77-9
• Molecular Formula: C₁₅H₂₃ClN₂O₃
• Molecular Weight: 314.812
• Mol file: 1093868-77-9.mol

Synonyms:methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate

Chemical Property of methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate

There total 8 articles about methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-(2-(methoxycarbonyl)aminoethoxy)-3-(2-methyl-5-chlorophenyl)propyl(methyl)carbamate (1093868-76-8) → methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate (1093868-77-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

tert-butyl 3-(5-chloro-2-methylphenyl)-3-oxopropyl(methyl)carbamate (1093868-70-2) → methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate (1093868-77-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.2: 20 °C

3.1: sodium tetrahydroborate / methanol / 2 - 3 h / 20 - 40 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 80 °C

6.1: water; triphenylphosphine / tetrahydrofuran / 20 °C

7.1: triethylamine / dmap / dichloromethane / 1 - 2 h / 0 - 5 °C

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium tetrahydroborate; sodium azide; water; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; dmap; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 3-(5-chloro-2-methylphenyl)-3-(2-hydroxyethoxy)propyl(methyl)carbamate (1093868-73-5) → methyl 2-(1-(5-chloro-2-methylphenyl)-3-(methylamino)propoxy)ethylcarbamate (1093868-77-9)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 80 °C

3: water; triphenylphosphine / tetrahydrofuran / 20 °C

4: triethylamine / dmap / dichloromethane / 1 - 2 h / 0 - 5 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium azide; water; triethylamine; triphenylphosphine; trifluoroacetic acid; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 3-(2-(methoxycarbonyl)aminoethoxy)-3-(2-methyl-5-chlorophenyl)propyl(methyl)carbamate

tert-butyl 3-(5-chloro-2-methylphenyl)-3-oxopropyl(methyl)carbamate

tert-butyl 3-(5-chloro-2-methylphenyl)-3-hydroxypropyl(methyl)carbamate

tert-butyl 3-(5-chloro-2-methylphenyl)-3-(2-hydroxyethoxy)propyl(methyl)carbamate

Refernces