Technology Process of 6-hydroxy-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one
There total 12 articles about 6-hydroxy-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-methionine;
In
methanesulfonic acid;
at 100 ℃;
for 6.5h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / benzene / 3.5 h / 75 °C
2.1: ammonia / tetrahydrofuran / 12 h / 0 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C
4.1: pyridine / chloroform / 24 h / 20 °C
5.1: sodium hydroxide / water / 20 °C / Heating / reflux
5.2: 20 °C / pH 7
6.1: methanesulfonic acid; L-methionine / 6.5 h / 100 °C
With
pyridine; sodium hydroxide; thionyl chloride; methanesulfonic acid; L-methionine; ammonia; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C
2.1: pyridine / chloroform / 24 h / 20 °C
3.1: sodium hydroxide / water / 20 °C / Heating / reflux
3.2: 20 °C / pH 7
4.1: methanesulfonic acid; L-methionine / 6.5 h / 100 °C
With
pyridine; sodium hydroxide; methanesulfonic acid; L-methionine; hydrogen;
palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; chloroform; water;
