(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

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Chemical Name:(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester
CAS No.:866115-05-1
Molecular Formula:C₄₈H₄₄N₂O₁₀
Molecular Weight:808.885
Hs Code.:

(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

Synonyms:(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

There total 12 articles about (S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 866115-04-0
(S)-2-Benzyloxycarbonylamino-3-[3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-(4-methoxy-benzyloxy)-phenyl]-propionic acid benzyl ester

: 866115-05-1
(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 24h; Heating;
DOI:10.1021/jo051076m

Reference yield:

: 866114-99-0
(S)-2-Benzyloxycarbonylamino-3-[3-iodo-4-(4-methoxy-benzyloxy)-phenyl]-propionic acid benzyl ester

: 866115-05-1
(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(dppf)Cl₂*CH₂Cl₂; KOAc; bis(neopentylglycolato)diboron / dimethylsulfoxide / 6 h / 80 °C

1.2: 89 percent / H₂O / ethyl acetate / 20 h / 20 °C

2.1: 81 percent / aq. H₂O₂ / methanol / 0.5 h / 20 °C

3.1: 80 percent / Cu(OAc)2; pyridine / CH₂Cl₂ / 48 h / 20 °C

4.1: 78 percent / DDQ / CH₂Cl₂; H₂O / 24 h / Heating

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper diacetate; dihydrogen peroxide; potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo051076m

Reference yield:

: 5513-40-6
benzyl N-carbobenzyloxy-L-tyrosine

: 866115-05-1
(S)-2-Benzyloxycarbonylamino-3-{3-[4-((S)-2-benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 43 percent / silver sulfate; iodine / methanol / 5 h / 20 °C

2.1: K₂CO₃; tetrabutylammonium iodide / acetone / 0.5 h / 20 °C

2.2: 76 percent / acetone / 24 h / Heating

3.1: Pd(dppf)Cl₂*CH₂Cl₂; KOAc; bis(neopentylglycolato)diboron / dimethylsulfoxide / 6 h / 80 °C

3.2: 89 percent / H₂O / ethyl acetate / 20 h / 20 °C

4.1: 81 percent / aq. H₂O₂ / methanol / 0.5 h / 20 °C

5.1: 80 percent / Cu(OAc)2; pyridine / CH₂Cl₂ / 48 h / 20 °C

6.1: 78 percent / DDQ / CH₂Cl₂; H₂O / 24 h / Heating

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper diacetate; dihydrogen peroxide; iodine; potassium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; silver sulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jo051076m