4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Base Information

• Chemical Name: 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride
• CAS No.: 432029-33-9
• Molecular Formula: C₂₁H₂₄BrClN₄O₃*ClH
• Molecular Weight: 532.264
• Mol file: 432029-33-9.mol

Synonyms:4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Chemical Property of 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

There total 7 articles about 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1-(1-methylethyl)-4-piperidine carboxylic acid (280771-97-3) + 2-amino-5-bromo-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-84-6) → 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride (432029-33-9)

Guidance literature:

1-(1-methylethyl)-4-piperidine carboxylic acid; 2-amino-5-bromo-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 30h;

DOI:10.1016/j.bmc.2014.09.059

Reference yield:

1-(1-methylethyl)-4-piperidine carboxylic acid (280771-97-3) + ethyl-3-(dimethylamino)propyl carbodiimide, hydrochloride salt + 2-amino-5-bromo-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-84-6) → 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride (432029-33-9)

Guidance literature:

With hydrogenchloride; benzotriazol-1-ol; triethylamine; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

3-benzyloxy-N-(5-chloro-2-pyridyl)-2-nitrobenzamide → 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride (432029-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pentamethylbenzene,; trifluoroacetic acid / 23 h / 40 °C

2.1: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / -15 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

4.2: 30 h / 20 °C

With N-Bromosuccinimide; pentamethylbenzene,; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.09.059

upstream raw materials:

1-(1-methylethyl)-4-piperidine carboxylic acid

2-amino-5-bromo-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

2-amino-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

3-benzyloxy-2-nitrobenzoic acid