((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

Base Information

Chemical Name:((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate
CAS No.:1581704-58-6
Molecular Formula:C₅₃H₅₅F₆N₄O₉P
Molecular Weight:1037.01
Hs Code.:

((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

Synonyms:((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

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Chemical Property of ((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

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Technology Process of ((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

There total 6 articles about ((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1581704-54-2
(2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

: 153910-62-4
3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid

: 1581704-58-6
((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

Guidance literature:: (2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; With sulfuryl dichloride; N,N-diethylethanamine hydrochloride; In dichloromethane; at 0 - 20 ℃; for 1h;

3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 129967-42-6
2‐(3‐hydroxy‐1,1‐dimethylpropyl)‐3,5‐dimethylphenol

: 1581704-58-6
((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 60 °C

3.1: potassium iodide / acetone / 0.17 h / 0 °C

3.2: 4 h / 0 - 20 °C

4.1: N,N-diethylethanamine hydrochloride; sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

4.2: 4 h / 20 °C

With 1H-imidazole; sulfuryl dichloride; N,N-diethylethanamine hydrochloride; potassium tert-butylate; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 40662-14-4
4,4,5,7-tetramethyl-3,4-dihydrocoumarin

: 1581704-58-6
((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 60 °C

4.1: potassium iodide / acetone / 0.17 h / 0 °C

4.2: 4 h / 0 - 20 °C

5.1: N,N-diethylethanamine hydrochloride; sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

5.2: 4 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; sulfuryl dichloride; N,N-diethylethanamine hydrochloride; potassium tert-butylate; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;