(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate
CAS No.:1195785-24-0
Molecular Formula:C₃₀H₃₅BrN₂O₆
Molecular Weight:599.522
Hs Code.:

Synonyms:(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

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Chemical Property of (R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

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Technology Process of (R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

There total 1 articles about (R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1195785-23-9
(R)-tert-butyl 1-(3'-amino-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

: 108-24-7
acetic anhydride

: 1195785-24-0
(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

Guidance literature:: In dichloromethane; for 1h;
DOI:10.1021/ja907193b

Reference yield:

: 1195785-24-0
(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

: C₂₅H₂₇BrN₂O₄

Guidance literature:: With formic acid; at 23 ℃; for 4h;
DOI:10.1021/ja907193b

Reference yield:

: 1195785-24-0
(R)-tert-butyl 1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

: C₄₀H₅₂N₄O₆Si

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5: 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; triethylamine / acetonitrile; toluene / 1 h / Reflux; Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja3121394