6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

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Chemical Name:6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate
CAS No.:1364814-40-3
Molecular Formula:C₄₁H₄₁N₃O₈
Molecular Weight:703.792
Hs Code.:

Synonyms:6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

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Chemical Property of 6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

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Technology Process of 6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

There total 5 articles about 6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1364814-37-8
6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate

: 1364814-40-3
6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethyl acetate; for 24h; under 760.051 Torr;
DOI:10.1016/j.bmcl.2012.01.024

Reference yield:

: 1364814-32-3
C₃₁H₂₈N₂O₅

: 1364814-40-3
6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 760.05 Torr

With palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.01.024

Reference yield:

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 1364814-40-3
6-(1-(2-(benzo[d][1,3]dioxol-5-yl)-N-cyclopropylacetamido)-2-(benzylamino)-2-oxoethyl)naphthalen-2-yl 6-(2,5-dioxopyrrolidin-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroform / 1 h / 20 °C

1.2: 20 - 75 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 760.05 Torr

With palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform; ethyl acetate; 1.1: Ugi reaction / 1.2: Ugi reaction;
DOI:10.1016/j.bmcl.2012.01.024