N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide

Base Information

• Chemical Name: N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide
• CAS No.: 128398-42-5
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.352

Synonyms:N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide

Chemical Property of N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide

There total 2 articles about N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(benzoyl)amino-7,7-dimetyl-5-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-2-one (125812-05-7) → N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide (128398-42-5)

Guidance literature:

With sodium azide; sulfuric acid; In chloroform; 1.) 0 deg C, 1.5 h, 2.) RT, 2 h;

DOI:10.3987/COM-89-S8

Reference yield:

3-(benzoyl)amino-7,7-dimetyl-5-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-2-one (125812-05-7) → N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide (128398-42-5) + N-(8,8-dimethyl-2,6-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-b]azepin-3-yl)benzamide

Guidance literature:

With trimethylsilylazide; sulfuric acid; In dichloromethane; at -15 - 0 ℃; for 5h;

DOI:10.3987/com-01-s(k)53

Reference yield:

N-(8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydropyrano[3,2-c]azepin-3-yl)benzamide (128398-42-5) → N-(8,8-Dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,2-c]azepin-3-yl)-benzamide (128398-49-2)

Guidance literature:

With ammonia;

DOI:10.3987/COM-89-S8

upstream raw materials:

3-(benzoyl)amino-7,7-dimetyl-5-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-2-one

Downstream raw materials:

3-(benzoylamino)-2,5,6,7,8-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetic acid

N-(8,8-Dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,2-c]azepin-3-yl)-benzamide

N-(1-Amino-8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,2-c]azepin-3-yl)-benzamide

N-(1-Hydroxy-8,8-dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,2-c]azepin-3-yl)-benzamide

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