(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

Base Information

Chemical Name:(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone
CAS No.:1429504-75-5
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

Chemical Property:

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Technology Process of (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

There total 6 articles about (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51135-96-7
4-benzyl-4-hydroxypiperidine

: C₁₀H₈ClN₃O

: 1429504-75-5
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Reflux;

Reference yield:

: 1107659-33-5
ethyl 5-methyl-3-(pyridin-4-yl)-1H-pyrazole-4-carboxylate

: 1429504-75-5
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol / Reflux

2: thionyl chloride / 2 h / 70 °C

3: triethylamine / dichloromethane / 3 h / Reflux

With thionyl chloride; water; triethylamine; sodium hydroxide; In ethanol; dichloromethane;

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1429504-75-5
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / dichloromethane / 2 h / 70 °C

2: pyridine; magnesium chloride / dichloromethane / 0 - 35 °C

3: hydrazine / ethanol / 1 h / 10 - 35 °C

4: water; sodium hydroxide / ethanol / Reflux

5: thionyl chloride / 2 h / 70 °C

6: triethylamine / dichloromethane / 3 h / Reflux

With pyridine; thionyl chloride; water; triethylamine; sodium hydroxide; magnesium chloride; hydrazine; In ethanol; dichloromethane;