2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Base Information

Chemical Name:2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
CAS No.:1184955-90-5
Molecular Formula:C₁₄H₁₂FN₅O₂S
Molecular Weight:333.346
Hs Code.:

Synonyms:2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Suppliers and Price of 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

There total 6 articles about 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1072804-20-6
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid

: 1184955-90-5
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1016/j.bmc.2014.12.014

Reference yield:

: C₁₄H₁₃N₃O₆S

: 1184955-90-5
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / tetrahydrofuran / 2.5 h / 0 - 20 °C

2: toluene-4-sulfonic acid / ethanol / 2 h / Reflux

3: potassium carbonate / acetone / 5 h / Reflux

4: sodium hydroxide / ethanol; water / 1 h / Reflux

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonium chloride / N,N-dimethyl-formamide / 72 h / 20 °C

With potassium carbonate; ammonium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2014.12.014

Reference yield:

: 1072806-39-3
ethyl 2-(hydrazinecarboxamido)-4-methylthiazole-5-carboxylate

: 1184955-90-5
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / ethanol / 2 h / Reflux

2: potassium carbonate / acetone / 5 h / Reflux

3: sodium hydroxide / ethanol; water / 1 h / Reflux

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonium chloride / N,N-dimethyl-formamide / 72 h / 20 °C

With potassium carbonate; ammonium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2014.12.014