Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5

Base Information

• Chemical Name: Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5
• CAS No.: 118247-65-7
• Molecular Formula: C₃₅H₄₇N₅O₇
• Molecular Weight: 649.787
• Mol file: 118247-65-7.mol

Synonyms:Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5

Chemical Property of Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5

There total 7 articles about Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-3-benzyloxycarbonylamino-4-tert-butyoxycarbonylbutyric acid (83436-45-7) → Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5 (118247-65-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

2: dimethylformamide / 3 h / Ambient temperature

3: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

4: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

5: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

With hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

Reference yield:

Z-β-homo-Asp(OBut)-OMe (83436-44-6) → Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5 (118247-65-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 2 N NaOH / methanol / 0.5 h / 30 °C

2: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

3: dimethylformamide / 3 h / Ambient temperature

4: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

5: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

6: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

Reference yield:

Z-Asp(OBut)-CHN2 (118248-02-5) → Boc-Trp-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5 (118247-65-7)

Guidance literature:

Multi-step reaction with 7 steps

1: silver benzoate, triethylamine / 30 h / Ambient temperature

2: 2 N NaOH / methanol / 0.5 h / 30 °C

3: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

4: dimethylformamide / 3 h / Ambient temperature

5: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

6: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

7: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

With sodium hydroxide; hydrogen; silver benzoate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

upstream raw materials:

2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate

Boc-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5

(3R)-3-benzyloxycarbonylamino-4-tert-butyoxycarbonylbutyric acid

Z-β-homo-Asp(OBut)-OMe