1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione

Base Information

• Chemical Name: 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione
• CAS No.: 1310415-42-9
• Molecular Formula: C₁₄H₁₃NO₅S
• Molecular Weight: 307.327
• Mol file: 1310415-42-9.mol

Synonyms:1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione

Chemical Property of 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione

There total 8 articles about 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H23NO5SSi (1310415-41-8) → 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione (1310415-42-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol201236j

Reference yield:

C11H19NO3 (898404-90-5) → 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione (1310415-42-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4.2: 6 h / 20 °C / Inert atmosphere

5.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1021/ol201236j

Reference yield:

ethyl 1-((tert-butoxycarbonyl)amino)cyclopent-3-ene-1-carboxylate (207729-00-8) → 1-tosyl-3-oxa-1-azaspiro[4.4]non-8-ene-2,7-dione (1310415-42-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

5.2: 6 h / 20 °C / Inert atmosphere

6.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

With lithium borohydride; sodium hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1021/ol201236j

upstream raw materials:

C₁₁H₁₉NO₃

C₁₄H₁₅NO₄S

C₁₄H₁₅NO₅S

C₁₇H₂₃NO₅SSi

Downstream raw materials:

C₂₀H₂₇NO₅SSi