N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea

Base Information

• Chemical Name: N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea
• CAS No.: 266363-19-3
• Molecular Formula: C₂₄H₃₁N₃O₁₂S
• Molecular Weight: 585.589
• Mol file: 266363-19-3.mol

Synonyms:N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea

Chemical Property of N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea

There total 1 articles about N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetic anhydride (108-24-7) + N-(2S,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea → N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea (266363-19-3)

Guidance literature:

With sodium acetate; at 20 ℃; for 168h;

DOI:10.1016/S0040-4020(00)00022-3

Reference yield:

α-chlorophenylacetyl chloride (2912-62-1) + N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea (266363-19-3) → C32H35N3O13S

Guidance literature:

With triethylamine; In chloroform; for 3h; Heating;

DOI:10.1016/S0040-4020(00)00022-3

Reference yield:

N-(2S,3R,4S,5S)-2,3,4,5,6-pentaacetoxyhexyl-1-yl-N-methyl-N'-(4-nitro)phenylthiourea (266363-19-3) → 3,4-dimethoxycarbonyl-5-[N-(2S,3R,4S,5S)-2',3',4',5',6'-pentaacetoxyhexyl-1-yl]methylamino-2-phenylthiophene

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 3 h / Heating

2: CHCl₃ / 1 h / 20 °C

With triethylamine; In chloroform; 1: Condensation / 2: Cycloaddition;

DOI:10.1016/S0040-4020(00)00022-3

upstream raw materials:

acetic anhydride