compound with trifluoro-acetic acid

Base Information

• Chemical Name: compound with trifluoro-acetic acid
• CAS No.: 99281-88-6
• Molecular Formula: C₂HF₃O₂*C₅H₉NO₂
• Molecular Weight: 229.156
• Mol file: 99281-88-6.mol

Synonyms:(E)-methyl 4-aminobut-2-enoate trifluoroacetic acid salt

Chemical Property of compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(E)-Methyl4-aminobut-2-enoate2,2,2-trifluoroacetate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of compound with trifluoro-acetic acid

There total 1 articles about compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl (2E)-4-{[(tert-butoxy)carbonyl]amino}but-2-enoate (139200-36-5,87497-72-1) + trifluoroacetic acid (76-05-1) → (E)-methyl 4-aminobut-2-enoate trifluoroacetic acid salt (99281-88-6)

Guidance literature:

Ambient temperature;

DOI:10.1021/jm00084a012

Reference yield: 85.0%

1-benzoylisonipecotic acid (5274-99-7) + (E)-methyl 4-aminobut-2-enoate trifluoroacetic acid salt (99281-88-6) → (E)-methyl 4-(1-benzoylpiperidine-4-carboxamido)but-2-enoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Sealed tube;

DOI:10.1021/jacs.8b13193

Reference yield: 80.7%

4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzoic acid (333357-96-3) + (E)-methyl 4-aminobut-2-enoate trifluoroacetic acid salt (99281-88-6) → methyl (E)-4-(4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzamido)but-2-enoate

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; for 16h;

DOI:10.1021/jacs.5b06839

upstream raw materials:

methyl (2E)-4-{[(tert-butoxy)carbonyl]amino}but-2-enoate

trifluoroacetic acid

Downstream raw materials:

methyl N-benzoyl-γ-aminocrotonate

methyl N-dihydrocinnamoyl-γ-aminocrotonate

methyl N-(N'-acetyl-D-phenylalanyl)-γ-aminocrotonate

methyl N-(N'-acetyl-L-phenylalanyl)-4-amino-2-butenoate

Refernces

• 1、 -. "HETEROARYL INHIBITORS OF PAD4". Paragraph 00417-00418. . Retrieved 2018/03/28.
• 2、 Liu, Siming,Hanzlik, Robert P.. "Structure-Activity Relationships for Inhibition of Papain by Peptide Michael Acceptors". . p. 1067 - 1075. Retrieved 2007/10/02.