(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

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Chemical Name:(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester
CAS No.:83242-30-2
Molecular Formula:C₂₄H₂₂ClN₃O₄S₃
Molecular Weight:548.107
Hs Code.:

Synonyms:(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

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Chemical Property of (R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

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Technology Process of (R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

There total 3 articles about (R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 33405-92-4
2-benzothiazolylsulfenyl chloride

: 83290-70-4
2-(7-oxo-2,6-diaza-4-thiabicyclo<3.2.0>hept-2-en-6-yl)-3-chloromethyl-3-butenoate

: 83242-30-2
(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

Guidance literature:: In 1,4-dioxane; water; Ambient temperature;
DOI:10.1016/S0040-4039(00)87378-5

Reference yield:

: 61990-36-1
(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester

: 83242-30-2
(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaCl, H₂SO₄ / H₂O; CH₂Cl₂ / Ambient temperature; electrolysis with Pt electrodes at a constant current (10 mA/cm²), lower Cl(-) concentration

2: 61 percent / aqueous HCl

With hydrogenchloride; sulfuric acid; sodium chloride; In dichloromethane; water;
DOI:10.1002/bscb.19820911202

Reference yield:

: 91384-33-7
(R)-3-Chloromethyl-2-[(1R,5R)-3-(dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-but-3-enoic acid methyl ester

: 83242-30-2
(R)-2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-chloromethyl-but-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: zinc dust, AcOH / CH₂Cl₂ / 0 - 2 °C

2: 61 percent / aqueous HCl

With hydrogenchloride; acetic acid; zinc; In dichloromethane;
DOI:10.1002/bscb.19820911202