(R)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester
• CAS No.: 391248-15-0
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.288
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70374109
• Wikidata: Q82162604
• Mol file: 391248-15-0.mol

Synonyms:391248-15-0;(R)-4-CYANO-THIAZOLIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER;(r)-tert-butyl 4-cyanothiazolidine-3-carboxylate;tert-butyl (4R)-4-cyano-1,3-thiazolidine-3-carboxylate;(R)-3-BOC-4-CYANO-THIAZOLIDINE;SCHEMBL24532152;DTXSID70374109;MFCD02683054;AS-38105;CS-0171823;(r)-tert-butyl4-cyanothiazolidine-3-carboxylate;EN300-7411639;tert-Butyl(R)-4-cyanothiazolidine-3-carboxylate;(R)-4-Cyano-thiazolidine-3-carboxylic acidtert-butyl ester;(r)-4-cyanothiazolidine-3-carboxylic acid tert-butyl ester;(R)-4-CYANO-THIAZOLIDINE-3-CARBOXYLICACIDTERT-BUTYLESTER

Chemical Property of (R)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester

Chemical Property:

• Vapor Pressure: 3.13E-05mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 355.4°Cat760mmHg
• Flash Point: 168.8°C
• PSA: 78.63000
• Density: 1.2g/cm³
• LogP: 1.75788
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.07759887
• Heavy Atom Count: 14
• Complexity: 276

Purity/Quality:

98%min ^*data from raw suppliers

(R)-4-Cyano-thiazolidine-3-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CSCC1C#N
• Isomeric SMILES: CC(C)(C)OC(=O)N1CSC[C@H]1C#N

Technology Process of (R)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (R)-4-Cyano-thiazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

(4S)-3-(tert-Butyloxycarbonyl)thiazolidine-4-carboxamide (739365-93-6) → (4S)-N-boc-1,3-thiazolane-4-carbonitrile (884006-57-9,391248-15-0)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

(4S)-3-(tert-Butyloxycarbonyl)thiazolidine-4-carboxamide

Refernces

• 1、 -. "NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION". Page/Page column 46. . Retrieved 2008/06/13.