5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one
CAS No.:1246250-77-0
Molecular Formula:C₁₈H₁₇ClN₂O₃
Molecular Weight:344.798
Hs Code.:

Synonyms:5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

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Chemical Property of 5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

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Technology Process of 5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

There total 3 articles about 5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1039948-89-4
4-(2-hydroxy ethoxy)-3,5-dimethyl benzaldehyde

: 54166-95-9
2-amino-6-chlorobenzamide

: 1246250-77-0
5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 120 ℃; for 23h; Inert atmosphere;

Reference yield: 21.0%

: 1246250-77-0
5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

Guidance literature:

Reference yield:

: 2148-56-3
2-chloro-6-aminobenzoic acid

: 1246250-77-0
5-chloro-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 23 h / 20 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 23 h / 120 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide;