Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI)

Base Information

• Chemical Name: Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI)
• CAS No.: 302338-13-2
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.25
• Mol file: 302338-13-2.mol

Synonyms:Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI)

Chemical Property of Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI)

Chemical Property:

• PSA: 62.89000
• LogP: 2.57180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI)

There total 3 articles about Cyclopentanecarboxaldehyde, 2,2-dimethyl-1-(2-nitroethyl)-, (1S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethylcyclopentanecarboxaldehyde (70030-18-1) → (S)-2,2-Dimethyl-1-(2-nitro-ethyl)-cyclopentanecarbaldehyde (302338-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 Angstroem MS / benzene

2: N-ethylmorpholine / acetonitrile

With N-ethylmorpholine;; 4 Angstroem MS; In acetonitrile; benzene; 1: Condensation / 2: Addition;

DOI:10.1016/S0040-4039(00)01133-3

Reference yield:

2-nitroethyl acetate (18942-89-7) + (S)-1-[2,2-Dimethyl-cyclopent-(E)-ylidenemethyl]-2-methoxymethyl-pyrrolidine (325705-63-3) → (S)-2,2-Dimethyl-1-(2-nitro-ethyl)-cyclopentanecarbaldehyde (302338-13-2)

Guidance literature:

With N-ethylmorpholine;; In acetonitrile;

DOI:10.1016/S0040-4039(00)01133-3

Reference yield:

2-nitroethyl acetate (18942-89-7) + (S)-1-[2,2-Dimethyl-cyclopent-(E)-ylidenemethyl]-pyrrolidine-2-carboxylic acid tert-butyl ester → (S)-2,2-Dimethyl-1-(2-nitro-ethyl)-cyclopentanecarbaldehyde (302338-13-2)

Guidance literature:

With N-ethylmorpholine;; In acetonitrile;

DOI:10.1016/S0040-4039(00)01133-3

upstream raw materials:

2-nitroethyl acetate

(S)-1-[2,2-Dimethyl-cyclopent-(E)-ylidenemethyl]-2-methoxymethyl-pyrrolidine

2,2-dimethylcyclopentanecarboxaldehyde

Downstream raw materials:

(5S)-(+)-6,6-dimethyl-2-azaspiro[4.4]non-1-ene