(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid
CAS No.:174230-84-3
Molecular Formula:C₁₆H₁₇N₃O₆
Molecular Weight:347.327
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

There total 3 articles about (S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 69557-82-0
L-1-amino-3-(1-uracilyl)butyric acid

: 174230-84-3
(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

Guidance literature:: With sodium hydrogencarbonate; In toluene; for 2h;
DOI:10.1080/07328319608002398

Reference yield:

: 128563-64-4
L-1-tosylamino-3-(1-uracilyl)butyric acid

: 174230-84-3
(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / HBr, AcOH / 28 h / 40 °C

2: 99 percent / aq. NaHCO₃ / toluene / 2 h

With hydrogen bromide; sodium hydrogencarbonate; acetic acid; In toluene;
DOI:10.1080/07328319608002398

Reference yield:

: methyl 4-(β-methoxyacrylamidocarbonylamino)-1-(tosylamino)butyrate

: 174230-84-3
(S)-2-Benzyloxycarbonylamino-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / aq. NaOH / 3 h / 65 °C

2: 41 percent / HBr, AcOH / 28 h / 40 °C

3: 99 percent / aq. NaHCO₃ / toluene / 2 h

With sodium hydroxide; hydrogen bromide; sodium hydrogencarbonate; acetic acid; In toluene;
DOI:10.1080/07328319608002398