4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Base Information

Chemical Name:4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide
CAS No.:1445786-58-2
Molecular Formula:C₂₇H₂₉N₅O₅S
Molecular Weight:535.624
Hs Code.:

Synonyms:4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Chemical Property of 4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Technology Process of 4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

There total 5 articles about 4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 145659-70-7
1-(cyclohexyloxy)-3-nitrobenzene

: 1374867-87-4
7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-chloro-3-quinolinesulfonamide

: 1445786-58-2
4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: 1-(cyclohexyloxy)-3-nitrobenzene; With 5%-palladium/activated carbon; hydrogen; acetic acid; at 20 ℃; for 4h;

7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-chloro-3-quinolinesulfonamide; at 50 ℃; for 18h;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445786-58-2
4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3 h / Reflux

1.2: 0.25 h / 20 °C / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere

3.1: hydrogen; 5%-palladium/activated carbon; acetic acid / 4 h / 20 °C

3.2: 18 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445786-58-2
4-((3-(cyclohexyloxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: trichlorophosphate / 3 h / Reflux

2.2: 0.25 h / 20 °C / Cooling with ice

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere

4.1: hydrogen; 5%-palladium/activated carbon; acetic acid / 4 h / 20 °C

4.2: 18 h / 50 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water;