trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

Base Information

Chemical Name:trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide
CAS No.:1236357-71-3
Molecular Formula:C₂₂H₂₇N₅O₂S
Molecular Weight:425.555
Hs Code.:

Synonyms:trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

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Chemical Property of trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

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Technology Process of trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

There total 3 articles about trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1109277-35-1
trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-methylacetamide

: 1236357-71-3
trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 3h; Reflux;

Reference yield:

: 2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-methylacetamide

: 1236357-71-3
trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 3h; Reflux;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 1109276-89-2
2-((1r,4r)-4-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid

: 1236357-71-3
trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triaza-benzocyclohepten-6-yl)-phenyl]-cyclohexyl}-N-methylthioacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / 1,2-dichloro-ethane / 20 °C / Cooling with ice

1.2: 24 h

2.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

With Lawessons reagent; oxalyl dichloride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.06.045