(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

Base Information

Chemical Name:(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one
CAS No.:142687-80-7
Molecular Formula:C₁₅H₂₇NO₂
Molecular Weight:253.385
Hs Code.:

Synonyms:(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

There total 13 articles about (3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 142687-80-7
(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pt/C / acetic acid

2: SOCl₂

3: NEt₃ / CHCl₃

4: 72 percent / tetrahydrofuran

5: 1) NaH / 1) THF, 0 deg C, 2) THF, rt

6: LiOH, H₂O / methanol; tetrahydrofuran

7: DCC / tetrahydrofuran

8: 1) HCl, 2) aq. NaHCO₃ / 1) Et₂O

9: L-Selectride / -78 °C

10: H₂ / Pd/C / ethyl acetate

With hydrogenchloride; lithium hydroxide; thionyl chloride; water; hydrogen; L-Selectride; sodium hydride; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; platinum on activated charcoal; In tetrahydrofuran; methanol; chloroform; acetic acid; ethyl acetate;
DOI:10.1016/S0040-4039(00)79750-4

Reference yield:

: 27527-05-5
L-cyclohexylalanine

: 142687-80-7
(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: SOCl₂

2: NEt₃ / CHCl₃

3: 72 percent / tetrahydrofuran

4: 1) NaH / 1) THF, 0 deg C, 2) THF, rt

5: LiOH, H₂O / methanol; tetrahydrofuran

6: DCC / tetrahydrofuran

7: 1) HCl, 2) aq. NaHCO₃ / 1) Et₂O

8: L-Selectride / -78 °C

9: H₂ / Pd/C / ethyl acetate

With hydrogenchloride; lithium hydroxide; thionyl chloride; water; hydrogen; L-Selectride; sodium hydride; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate;
DOI:10.1016/S0040-4039(00)79750-4

Reference yield:

: 40056-18-6,789460-77-1
methyl L-cyclohexylalaninate

: 142687-80-7
(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: NEt₃ / CHCl₃

2: 72 percent / tetrahydrofuran

3: 1) NaH / 1) THF, 0 deg C, 2) THF, rt

4: LiOH, H₂O / methanol; tetrahydrofuran

5: DCC / tetrahydrofuran

6: 1) HCl, 2) aq. NaHCO₃ / 1) Et₂O

7: L-Selectride / -78 °C

8: H₂ / Pd/C / ethyl acetate

With hydrogenchloride; lithium hydroxide; water; hydrogen; L-Selectride; sodium hydride; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; ethyl acetate;
DOI:10.1016/S0040-4039(00)79750-4