N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Base Information

• Chemical Name: N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide
• CAS No.: 607741-05-9
• Molecular Formula: C₅₇H₆₀N₆O₇Si
• Molecular Weight: 969.225

Synonyms:N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Chemical Property of N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

There total 9 articles about N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-phthaloylglycine chloride (6780-38-7) + N-benzyl-2-benzylamino-N-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-acetamide (607740-97-6) → N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (607741-05-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; dichloromethane; at 25 ℃; for 3h;

DOI:10.1021/ja030297b

Reference yield:

N-benzylglycine (17136-36-6) → N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (607741-05-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 98 percent / Et₃N / H₂O / 3 h / 25 °C

2: 96 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

3: 94 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

4: 100 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

5: 96 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

6: 97 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

7: 96 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

8: 92 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

9: 91 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

10: 81 percent / Et₃N / CH₂Cl₂; dioxane / 3 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/ja030297b

Reference yield:

N-benzyl-N-(tert-butoxycarbonyl)glycine (76315-01-0) → N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (607741-05-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 96 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

2: 94 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

3: 100 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

4: 96 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

5: 97 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

6: 96 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

7: 92 percent / EEDQ / CH₂Cl₂ / 3 h / 25 °C

8: 91 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

9: 81 percent / Et₃N / CH₂Cl₂; dioxane / 3 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja030297b

upstream raw materials:

N-phthaloylglycine chloride

N-benzyl-2-benzylamino-N-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-acetamide

N-benzylglycine

N-benzyl-N-(tert-butoxycarbonyl)glycine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 607741-05-9 N-benzyl-N-[(benzyl-{[benzyl-({benzyl-[(benzyl-trimethylsilanylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send