2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole

Base Information

• Chemical Name: 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole
• CAS No.: 1158948-04-9
• Molecular Formula: C₁₀H₄Br₃F₂NO
• Molecular Weight: 431.857
• Mol file: 1158948-04-9.mol

Synonyms:2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole

Chemical Property of 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole

There total 7 articles about 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,3,4-tribromo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole (1158948-10-7) → 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole (1158948-04-9)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 0 ℃; for 1.5h;

DOI:10.1002/anie.200903743

Reference yield:

2-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole (1198777-68-2) → 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole (1158948-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: [Br⁺]

2: boron tribromide

With boron tribromide;

Reference yield:

N-(3,5-difluoro-2-methoxybenzylidene)-4-methylbenzenesulfonamide (1198777-57-9) → 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole (1158948-04-9)

Guidance literature:

Multi-step reaction with 6 steps

1: magnesium / diethyl ether / 15 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: silver(I) acetate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Reflux

4: potassium tert-butylate / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

5: pyridinium tribromide / ethanol / 0.5 h / 20 °C / Inert atmosphere

6: boron tribromide / dichloromethane / -78 - 0 °C / Inert atmosphere

With pyridinium tribromide; potassium tert-butylate; tetrabutyl ammonium fluoride; silver(I) acetate; boron tribromide; magnesium; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/ejoc.201402177

upstream raw materials:

2,3,4-tribromo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole

2-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole

N-(3,5-difluoro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

N-[1-(3,5-difluoro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide