4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole

Base Information

• Chemical Name: 4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole
• CAS No.: 1186206-91-6
• Molecular Formula: C₁₈H₂₃NO₄S
• Molecular Weight: 349.451
• Mol file: 1186206-91-6.mol

Synonyms:4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole

Chemical Property of 4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole

There total 1 articles about 4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,4-diisobutyryl-1-(phenylsulfonyl)-1H-pyrrole (1186206-90-5) → 2,4-bis(1-hydroxyisobutyl)-1-(phenylsulfonyl)-1H-pyrrole + 4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole (1186206-91-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; regioselective reaction;

DOI:10.1002/ejoc.200900331

Reference yield: 82.0%

4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole (1186206-91-6) → 4-isobutenyl-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole (1186206-95-0)

Guidance literature:

With aluminum oxide; In benzene; for 2h; Reflux;

DOI:10.1002/ejoc.200900331

Reference yield:

4-(1-hydroxyisobutyl)-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole (1186206-91-6) → 2,4-bis(1-hydroxyisobutyl)-1-(phenylsulfonyl)-1H-pyrrole

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1002/ejoc.200900331

upstream raw materials:

2,4-diisobutyryl-1-(phenylsulfonyl)-1H-pyrrole

Downstream raw materials:

4-isobutenyl-2-isobutyryl-1-(phenylsulfonyl)-1H-pyrrole