1,2-diethoxy-3,3,4,4-tetrafluoro-cyclobutene

Base Information

• Chemical Name: 1,2-diethoxy-3,3,4,4-tetrafluoro-cyclobutene
• CAS No.: 389-27-5
• Molecular Formula: C₈H₁₀F₄O₂
• Molecular Weight: 214.16
• Mol file: 389-27-5.mol

Synonyms:1,2-diethoxy-3,3,4,4-tetrafluoro-cyclobutene

Chemical Property of 1,2-diethoxy-3,3,4,4-tetrafluoro-cyclobutene

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Refernces

Determination of the binding site of chloro(triethylphosphine)gold(I) in serum albumin

10.1016/j.molstruc.2010.02.053

The study investigates the binding site of chloro(triethylphosphine)gold(I) (ClAuPEt3) in bovine serum albumin (BSA) using electron paramagnetic resonance (EPR) spectroscopy. The researchers employed 3-maleimidoPROXYL as a spin marker to identify the binding site of ClAuPEt3. They found that ClAuPEt3 competes with the spin marker for binding to the cysteine residue (Cys-34) in BSA. At low ClAuPEt3:BSA molar ratios, the spin marker with weak rotational limitation is more easily displaced than the strongly immobilized marker. However, as the ClAuPEt3:BSA molar ratio increases, the displacement of the strongly immobilized marker becomes more prevalent. The study suggests that ClAuPEt3 binding induces conformational changes in BSA, particularly affecting the Cys-34 residue. The findings provide insights into the interaction between gold compounds and serum albumin, which is relevant for understanding drug transport and therapeutic applications of gold(I) complexes in antirheumatic therapy.