2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

Base Information

Chemical Name:2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane
CAS No.:129611-59-2
Molecular Formula:C₁₆H₂₂OS₄
Molecular Weight:358.614
Hs Code.:

Synonyms:2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

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Chemical Property of 2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

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Technology Process of 2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

There total 10 articles about 2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120810-76-6
(2S,4S,5R)-4-Methyl-2-((E)-3-oxo-propenyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

: 129611-59-2
2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

Guidance literature:: Multi-step reaction with 8 steps

1: 78.5 percent / NaClO₂, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / Ambient temperature

2: 1. KOH, 2. Bu₄NHSO₄ / 1. methanol, RT, 5min; 2. CH₃CN, RT, overnight

3: 1. KH / 2. THF, RT, 18h; or with NaH

4: 90 percent / aq. NaOH / methanol / 72 h / Ambient temperature

5: (COCl)2, pyridine / benzene / Ambient temperature

6: diethyl ether / -78 - 0 °C

7: 1. ZnI₂ / 1. Et₂O, 5min; 2. 2h

8: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; zinc(II) iodide; In methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)89766-0

Reference yield:

: 120828-08-2
(2S,4S,5R)-4-Methyl-2-((E)-3-oxo-but-1-enyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

: 129611-59-2
2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

Guidance literature:: Multi-step reaction with 3 steps

1: 1. 60percent NaH / 1. THF, mineral oil, RT, 1h; 2. THF, -50 deg C, 18h; or with LiH

2: 1. ZnI₂ / 1. Et₂O, 5min; 2. 2h

3: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

With boron trifluoride diethyl etherate; sodium hydride; zinc(II) iodide; In dichloromethane;
DOI:10.1016/S0040-4020(01)89766-0

Reference yield:

: 129611-51-4
(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

: 129611-59-2
2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

Guidance literature:: Multi-step reaction with 7 steps

1: 1. KOH, 2. Bu₄NHSO₄ / 1. methanol, RT, 5min; 2. CH₃CN, RT, overnight

2: 1. KH / 2. THF, RT, 18h; or with NaH

3: 90 percent / aq. NaOH / methanol / 72 h / Ambient temperature

4: (COCl)2, pyridine / benzene / Ambient temperature

5: diethyl ether / -78 - 0 °C

6: 1. ZnI₂ / 1. Et₂O, 5min; 2. 2h

7: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; zinc(II) iodide; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)89766-0