Technology Process of 2-(3-cyanophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile
There total 4 articles about 2-(3-cyanophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 70 ℃;
for 3h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jo4020326
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; ammonium acetate / toluene / 2 h / 180 °C / Dean-Stark
2.1: triethylamine / dichloromethane / 2 h / -78 °C / Inert atmosphere
3.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
3.2: 2 h / 0 °C / Inert atmosphere; Reflux
4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); ammonium acetate; trityl tetrafluoroborate; acetic acid; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
1.1: |Knoevenagel Condensation;
DOI:10.1021/jo4020326
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 2 h / -78 °C / Inert atmosphere
2.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
2.2: 2 h / 0 °C / Inert atmosphere; Reflux
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); trityl tetrafluoroborate; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo4020326
