BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID
• CAS No.: 301226-53-9
• Molecular Formula: C₁₆H₂₀FNO₄
• Molecular Weight: 309.338
• Hs Code.: 2933990090
• Mol file: 301226-53-9.mol

Synonyms:BOC-TRANS-DL-PRO(3-FLUOROPHENYL)-OH;BOC-(+/-)-TRANS-4-(3-FLUOROPHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID;BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID;BOC-DL-TRANS-4-(3-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID;Boc-trans-DL-b-Pro-4-(3-fluorophenyl)-OH

Chemical Property of BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.02E-08mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 437.3°Cat760mmHg
• PKA: 4.26±0.40(Predicted)
• Flash Point: 218.3°C
• PSA: 66.84000
• Density: 1.249g/cm³
• LogP: 2.79870
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-(±)-trans-4-(3-fluorophenyl)pyrrolidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Boc-(±)-trans-4-(3-fluorophenyl)pyrrolidine-3-carboxylic Acid is used to prepare pyrrolidinylurea and pyrrolidinylthiourea compounds as TrkA kinase inhibitors.

Technology Process of BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID

There total 3 articles about BOC-(TRANS)-4-(3-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(3-Fluoro-phenyl)-2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butyl ester (951742-92-0) → (-)-4-(3-fluoro-phenyl)-pyrrolidine-1,3-dicarboxylic acid-1-tert-butyl ester (951742-94-2,939757-99-0,301226-53-9)

Guidance literature:

4-(3-Fluoro-phenyl)-2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butyl ester; With hydrogen; triethylamine; [Ru(OAc)2 ((R)-(2-furyl)-(6,6'-dimethoxy[1,1'-biphenyl]-2,2'-diyl)bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine])]; In methanol; at 80 ℃; for 42h; under 30003 Torr;

With sodium hydroxide; In methanol; tert-butyl methyl ether; water;

With hydrogenchloride; In water; at 0 ℃; pH=1; Product distribution / selectivity;

Reference yield: 86.0%

→ (±)-trans-1-(tert-butoxycarbonyl)-4-(3-fluorophenyl)pyrrolidine-3-carboxylic acid (939757-99-0,301226-53-9)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 77.0%

4-(3-Fluoro-phenyl)-2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butyl ester (951742-92-0) → (+)-4-(3-fluoro-phenyl)-pyrrolidine-1,3-dicarboxylic acid-1-tert-butyl ester (939757-99-0,301226-53-9)

Guidance literature:

4-(3-Fluoro-phenyl)-2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butyl ester; With hydrogen; triethylamine; [Ru(OAc)2((S)-(6-MeO-2-Naphthyl)-MeOBIPHEP)]; In methanol; at 80 ℃; for 42h; under 30003 Torr;

With sodium hydroxide; In methanol; tert-butyl methyl ether; water;

With hydrogenchloride; In water; at 0 ℃; pH=1; Product distribution / selectivity;

upstream raw materials:

4-(3-Fluoro-phenyl)-2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butyl ester

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