Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-

Base Information

• Chemical Name: Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-
• CAS No.: 301206-12-2
• Molecular Formula: C₂₈H₂₂N₄O₆
• Molecular Weight: 510.506
• Mol file: 301206-12-2.mol

Synonyms:Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-

Chemical Property of Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-

There total 6 articles about Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5,6-diamino-3-methyl-1-phenyluracil (50786-93-1) + 2-((4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid (97980-65-9) → N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetamide (301206-12-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

7-hydroxyflavone (6665-86-7,66585-10-2) → N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetamide (301206-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: 3N NaOH / ethanol

3: 61 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (42212-19-1) → N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetamide (301206-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂; 5N HCl

1.2: H₂ / Pd-C / ethanol / Heating

2.1: 61 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In N,N-dimethyl-formamide; 1.1: Nitrosation / 1.2: Catalytic hydrogenation / 2.1: Acylation;

DOI:10.1016/S0968-0896(00)00126-7

upstream raw materials:

5,6-diamino-3-methyl-1-phenyluracil

2-((4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid

7-hydroxyflavone

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione