ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

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Chemical Name:ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate
CAS No.:744250-77-9
Molecular Formula:C₂₇H₄₃N₃O₇
Molecular Weight:521.654
Hs Code.:

Synonyms:ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

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Chemical Property of ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

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Technology Process of ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

There total 1 articles about ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

: 746657-36-3,213316-32-6,259221-73-3
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate

: 744250-70-2
C₁₉H₃₂N₂O₆

: 744250-77-9
ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 5h;

Reference yield:

: 744250-77-9
ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

: 1216941-64-8
(2S,6S,13aS,14aR,16aS,Z)-ethyl 2-(4-bromophenylsulfonyloxy)-6-(tert-butoxycarbonylamino)-5,16-dioxo-1,2,3,5, 6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydronaphthylcyclopropanoyl[e]pyrrolo[1,2-a][1,4] diazacyclopentadecyne-14a-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst first generation / dichloromethane / 12 h / Inert atmosphere; Reflux

2: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; Hoveyda-Grubbs catalyst first generation; In dichloromethane; toluene;

Reference yield:

: 744250-77-9
ethyl (1R,2S)-1-({(4S)-1-[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-8-nonenoyl]-4-hydroxy-L-prolyl}amino)-2-ethenylcyclopropanecarboxylate

: C₃₉H₄₆BrN₅O₇

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst first generation / dichloromethane / 12 h / Reflux; Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 5 - 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; Hoveyda-Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;