1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester
• CAS No.: 181235-18-7
• Molecular Formula: C₂₃H₂₆O₄
• Molecular Weight: 366.457
• Mol file: 181235-18-7.mol

Synonyms:1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester

Chemical Property of 1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester

There total 1 articles about 1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bromoacetic acid tert-butyl ester (5292-43-3) + benzyl 2,3-dihydro-1H-indene-1-carboxylate → 1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester (181235-18-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0960-894X(96)00303-4

Reference yield:

1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester (181235-18-7) → {1-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-indan-1-yl}-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: DEC, HOBT / CH₂Cl₂; triethylamine

3: TFA / CH₂Cl₂

With diethylcarbamazine; hydrogen; benzotriazol-1-ol; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; triethylamine;

DOI:10.1016/0960-894X(96)00303-4

Reference yield:

1-tert-Butoxycarbonylmethyl-indan-1-carboxylic acid benzyl ester (181235-18-7) → 1-Hydroxycarbamoylmethyl-indan-1-carboxylic acid [(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-amide

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethanol

2: DEC, HOBT / CH₂Cl₂; triethylamine

3: TFA / CH₂Cl₂

4: BOP / CH₂Cl₂; triethylamine

5: H₂ / Pd/C / methanol

With diethylcarbamazine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; triethylamine;

DOI:10.1016/0960-894X(96)00303-4

upstream raw materials:

bromoacetic acid tert-butyl ester