2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo-

Base Information

Chemical Name:2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo-
CAS No.:301206-09-7
Molecular Formula:C₂₁H₁₆N₄O₅
Molecular Weight:404.382
Hs Code.:
Mol file:301206-09-7.mol

Synonyms:2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo-

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

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Technology Process of 2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo-

There total 4 articles about 2H-1-Benzopyran-3-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

: 531-81-7
2-oxo-2H-chromene-3-carboxylic acid

: 50786-93-1
5,6-diamino-3-methyl-1-phenyluracil

: 301206-09-7
2-oxo-2H-chromene-3-carboxylic acid (6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 42212-19-1
6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione

: 301206-09-7
2-oxo-2H-chromene-3-carboxylic acid (6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaNO₂; 5N HCl

1.2: H₂ / Pd-C / ethanol / Heating

2.1: 79.4 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In N,N-dimethyl-formamide; 1.1: Nitrosation / 1.2: Catalytic hydrogenation / 2.1: Acylation;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 72702-74-0
N-cyanoacetyl-N-methyl-N'-phenyl-urea

: 301206-09-7
2-oxo-2H-chromene-3-carboxylic acid (6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2N NaOH

2.1: NaNO₂; 5N HCl

2.2: H₂ / Pd-C / ethanol / Heating

3.1: 79.4 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In N,N-dimethyl-formamide; 1.1: Cyclization / 2.1: Nitrosation / 2.2: Catalytic hydrogenation / 3.1: Acylation;
DOI:10.1016/S0968-0896(00)00126-7