Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-

Base Information

Chemical Name:Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-
CAS No.:301206-08-6
Molecular Formula:C₂₄H₂₂N₄O₆
Molecular Weight:462.462
Hs Code.:
Mol file:301206-08-6.mol

Synonyms:Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-

Chemical Property:

PSA：138.56000
LogP:2.67670

Purity/Quality:

Safty Information:

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Technology Process of Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-

There total 6 articles about Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.4%

: 50786-93-1
5,6-diamino-3-methyl-1-phenyluracil

: 126051-09-0
4-(2-oxo-2H-chromen-7-yloxy)butanoic acid

: 301206-08-6
N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-(2-oxo-2H-chromen-7-yloxy)-butyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 93-35-6
7-hydroxy-2H-chromen-2-one

: 301206-08-6
N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-(2-oxo-2H-chromen-7-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: 3N NaOH / ethanol

3: 66.4 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrolysis / 3: Acylation;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 42212-19-1
6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione

: 301206-08-6
N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-(2-oxo-2H-chromen-7-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaNO₂; 5N HCl

1.2: H₂ / Pd-C / ethanol / Heating

2.1: 66.4 percent / HOBt; EDC*HCl / dimethylformamide / 6 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In N,N-dimethyl-formamide; 1.1: Nitrosation / 1.2: Catalytic hydrogenation / 2.1: Acylation;
DOI:10.1016/S0968-0896(00)00126-7