trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

Base Information

Chemical Name:trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate
CAS No.:873783-99-4
Molecular Formula:C₂₇H₄₃N₅O₈
Molecular Weight:565.667
Hs Code.:

Synonyms:trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

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Chemical Property of trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

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Technology Process of trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

There total 1 articles about trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 116052-94-9
2-(S)-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

: 115724-80-6
(R)-2-trifluoromethanesulfonyloxy-propionic acid methyl ester

: 873783-99-4
trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 96h;
DOI:10.1039/b510778d

Reference yield: 40.0%

: 873783-99-4
trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

: 96-32-2
bromoacetic acid methyl ester

: 873784-01-1
tetramethyl (4S,7S,10S)-α,α',α''-trimethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 96h;
DOI:10.1039/b510778d

Reference yield:

: 873783-99-4
trimethyl (4S,7S,10S)-α,α',α''-tetramethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate

: (4S,7S,10S)-α,α',α''-trimethyl[(S)-2-(nitrobenzyl)]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / potassium carbonate / acetonitrile / 96 h / 60 °C

2: 82 percent / aq. sodium hydroxide / tetrahydrofuran / 24 h / 55 °C

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b510778d