Technology Process of Piperidin-2-yl-p-tolyl-acetic acid
There total 4 articles about Piperidin-2-yl-p-tolyl-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) t-BuOK / 1.) THF, RT, 0.5 h, 2.) THF, a) RT, 1 h, b) reflux, overnight
2: 12 N HCl / 15 h / Ambient temperature
3: H2 / 5percent Pt/C / acetic acid / 10 h / 1551.4 - 2068.6 Torr
4: 1.) 6N HCl, 2.) 50percent KOH / 1.) reflux, 6 h, 2.) reflux, 4 d
With
hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrogen;
platinum on activated charcoal;
In
acetic acid;
DOI:10.1021/jm950697c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) t-BuOK / 1.) THF, RT, 0.5 h, 2.) THF, a) RT, 1 h, b) reflux, overnight
2: 12 N HCl / 15 h / Ambient temperature
3: H2 / 5percent Pt/C / acetic acid / 10 h / 1551.4 - 2068.6 Torr
4: 1.) 6N HCl, 2.) 50percent KOH / 1.) reflux, 6 h, 2.) reflux, 4 d
With
hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrogen;
platinum on activated charcoal;
In
acetic acid;
DOI:10.1021/jm950697c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 12 N HCl / 15 h / Ambient temperature
2: H2 / 5percent Pt/C / acetic acid / 10 h / 1551.4 - 2068.6 Torr
3: 1.) 6N HCl, 2.) 50percent KOH / 1.) reflux, 6 h, 2.) reflux, 4 d
With
hydrogenchloride; potassium hydroxide; hydrogen;
platinum on activated charcoal;
In
acetic acid;
DOI:10.1021/jm950697c
