Technology Process of 2,6-dimethoxy-4-methoxymethylaniline
There total 1 articles about 2,6-dimethoxy-4-methoxymethylaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-1,3-dimethoxy-5-(methoxymethyl)benzene;
With
n-butyllithium; diphenylphosphoranyl azide;
In
tetrahydrofuran;
at -78 - -15 ℃;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2012.05.066
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate;
In
toluene;
Reflux;
DOI:10.1016/j.bmcl.2012.05.066
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate / toluene / Reflux
2: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C
3: 2-methylpyridine borane complex; acetic acid / methanol / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); 2-methylpyridine borane complex; palladium on activated charcoal; hydrogen; acetic acid; johnphos; sodium t-butanolate;
In
methanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2012.05.066
