tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate
CAS No.:1190370-13-8
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 22312-77-2
2-chloromethyl-3-phenyl-3H-quinazolin-4-one

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1190370-13-8
tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃;
DOI:10.1080/00397910902735381

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1190370-13-8
tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: pyridine / Reflux

3: potassium carbonate; potassium iodide / acetonitrile / 80 °C

With pyridine; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.1080/00397910902735381

Reference yield:

: 98592-35-9
2-(chloromethyl)-4H-benzo[d][1,3]oxazin-4-one

: 1190370-13-8
tert-butyl 4-[(3,4-dihydro-4-oxo-3-phenylquinazolin-2-yl)methyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / Reflux

2: potassium carbonate; potassium iodide / acetonitrile / 80 °C

With pyridine; potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1080/00397910902735381