Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-

Base Information

• Chemical Name: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-
• CAS No.: 301206-01-9
• Molecular Formula: C₂₂H₂₂N₄O₅
• Molecular Weight: 422.44
• Mol file: 301206-01-9.mol

Synonyms:Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-

Chemical Property of Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-

Chemical Property:

• PSA: 125.42000
• LogP: 2.56700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-

There total 6 articles about Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.6%

5,6-diamino-3-methyl-1-phenyluracil (50786-93-1) + 3,5-dimethyl-4-acetoxybenzoic acid (23298-94-4) → acetic acid 4-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-2,6-dimethyl-phenyl ester (301206-01-9)

Guidance literature:

With triethylamine; Diphenylphosphinic chloride; In dichloromethane; at 0 ℃;

DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (42212-19-1) → acetic acid 4-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-2,6-dimethyl-phenyl ester (301206-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂; aq. HCl / 20 °C

2: H₂ / 5 percent Pd/C / methanol

3: Et₃N; diphenylphosphoryl chloride / CH₂Cl₂

With hydrogenchloride; hydrogen; triethylamine; sodium nitrite; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1248/cpb.51.309

Reference yield:

6-amino-3-methyl-5-nitro-1-phenyl-1H-pyrimidine-2,4-dione → acetic acid 4-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-2,6-dimethyl-phenyl ester (301206-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol

2: Et₃N; diphenylphosphoryl chloride / CH₂Cl₂

With hydrogen; triethylamine; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1248/cpb.51.309

upstream raw materials:

5,6-diamino-3-methyl-1-phenyluracil

3,5-dimethyl-4-acetoxybenzoic acid

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione

3,5-dimethyl-4-hydroxybenzoic acid