4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

Base Information

Chemical Name:4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester
CAS No.:217435-81-9
Molecular Formula:C₂₇H₃₆O₅Si
Molecular Weight:468.665
Hs Code.:

Synonyms:4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

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Chemical Property of 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

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Technology Process of 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

There total 6 articles about 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 217435-80-8
2-Diazo-malonic acid 5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentyl ester methyl ester

: Acetic acid 2-[4-(tert-butyl-diphenyl-silanyloxy)-1-ethyl-butyl]-4-oxo-oxetan-3-yl ester

: 217435-81-9
4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

: 2-Hydroxy-malonic acid 5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentyl ester methyl ester

: 2-{[5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-pentyloxycarbonyl]-methoxycarbonyl-methoxy}-malonic acid 5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentyl ester methyl ester

Guidance literature:: dirhodium tetraacetate; In dichloromethane; for 10h; Heating;
DOI:10.1016/S0040-4020(98)00825-4

Reference yield:

: Malonic acid 2-ethyl-pent-4-enyl ester methyl ester

: 217435-81-9
4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) disiamylborane, 2.) H₂O₂, aq. NaOH / 1.) THF, 0 deg C, 30 min; room temperature, 30 min, 2.) 10-20 deg C, 20 min

2: 89 percent / pyridine / 12 h / 0 - 20 °C

3: 88 percent / MsN₃, Et₃N / acetonitrile / 1.) 0 deg C, 30 min, 2.) room temperature, 10 h

4: 90 percent / Rh₂(OAc)4 / CH₂Cl₂ / 10 h / Heating

With pyridine; sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; triethylamine; Methanesulfonyl azide; dirhodium tetraacetate; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(98)00825-4

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 217435-81-9
4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / pyridine / 12 h / 0 - 20 °C

2: 88 percent / MsN₃, Et₃N / acetonitrile / 1.) 0 deg C, 30 min, 2.) room temperature, 10 h

3: 90 percent / Rh₂(OAc)4 / CH₂Cl₂ / 10 h / Heating

With pyridine; triethylamine; Methanesulfonyl azide; dirhodium tetraacetate; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(98)00825-4