4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

Base Information

Chemical Name:4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one
CAS No.:1237737-69-7
Molecular Formula:C₁₉H₁₈BrNO₄
Molecular Weight:404.26
Hs Code.:

Synonyms:4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

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Chemical Property of 4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

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Technology Process of 4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

There total 6 articles about 4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₂₈H₃₄BrNO₈

: 1237737-69-7
4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

Guidance literature:: With chlorotriisopropylsilane; water; trifluoroacetic acid; at 20 ℃; for 1.5h;
DOI:10.1111/j.1747-0285.2010.00984.x

Reference yield:

: 1237737-63-1
C₂₁H₂₈BNO₃

: 1237737-69-7
4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 0 - 20 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation

3: chlorotriisopropylsilane; water; trifluoroacetic acid / 1.5 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; water; triethylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; methanol; water; 2: Suzuki coupling;
DOI:10.1111/j.1747-0285.2010.00984.x

Reference yield:

: 1237737-57-3
C₂₆H₃₆BNO₅

: 1237737-69-7
4-[3-(benzylaminomethyl)-4-methoxyphenyl]-3-bromo-5-hydroxy-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation

2: chlorotriisopropylsilane; water; trifluoroacetic acid / 1.5 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; water; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; water; 1: Suzuki coupling;
DOI:10.1111/j.1747-0285.2010.00984.x