(S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one

Base Information

• Chemical Name: (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one
• CAS No.: 1044204-03-6
• Molecular Formula: C₁₉H₁₆F₃NO₄
• Molecular Weight: 379.336
• Mol file: 1044204-03-6.mol

Synonyms:(S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one

Chemical Property of (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one

There total 2 articles about (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2) → (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one (1044204-03-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

DOI:10.1016/j.tetasy.2008.04.032

Reference yield: 33.0%

pentafluorophenyl trifluoromethyl-methoxy-phenylacetate (1044203-86-2) + (4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2) → (R,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one (1044204-05-8) + (S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one (1044204-03-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

DOI:10.1016/j.tetasy.2008.04.032

Reference yield: 80.0%

(S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one (1044204-03-6) → C18H18F3NO3 (1044204-62-7) + (S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) + (4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2008.04.032

upstream raw materials:

pentafluorophenyl trifluoromethyl-methoxy-phenylacetate

(4R)-phenyl-2-oxazolidinone

(R)-methoxytrifluoromethylphenylacetyl chloride

Downstream raw materials:

C₁₈H₁₈F₃NO₃

(S)-Mosher acid

(4R)-phenyl-2-oxazolidinone

C₂₃H₂₆F₃NO₅