(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

Base Information

Chemical Name:(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester
CAS No.:869116-01-8
Molecular Formula:C₁₈H₁₅IN₂O₆S
Molecular Weight:514.297
Hs Code.:

Synonyms:(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

There total 1 articles about (S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (S)-2-(2-Nitro-benzenesulfonylamino)-pent-4-ynoic acid methyl ester

: 615-42-9
1,2-Diiodobenzene

: 869116-01-8
(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

Guidance literature:: With ammonium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2005.07.016

Reference yield: 79.0%

: 869116-01-8
(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

: 107-19-7
propargyl alcohol

: 869116-05-2
(S)-2-(2-nitrobenzenesulfonylamino)-5-[2-(3-hydroxyprop-1-ynyl)phenyl]pent-4-ynoic acid methyl ester

Guidance literature:: With ammonium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 20 ℃;
DOI:10.1016/j.bmc.2005.07.016

Reference yield:

: 869116-01-8
(S)-2-(2-nitrobenzenesulfonylamino)-5-(2-iodophenyl)pent-4-ynoic acid methyl ester

: 869115-85-5
C₂₁H₁₆N₂O₆S

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / aq. ammonia; CuI / Pd(PPh₃)2Cl₂ / 1,2-dimethoxy-ethane / 20 °C

2: 77 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / cooling

With ammonium hydroxide; copper(l) iodide; triphenylphosphine; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; 1: Sonogashira coupling / 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2005.07.016