(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:503822-44-4
Molecular Formula:C₁₉H₂₃NO
Molecular Weight:281.398
Hs Code.:

Synonyms:(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 503822-38-6
(3R,6R)-6-ethyl-3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline

: 503822-44-4
(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h;
DOI:10.3987/com-02-s(m)42

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 503822-44-4
(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

1.2: 85 percent / NaBH₄ / methanol / 2 h / 20 °C

2.1: benzene / 2 h / Heating

3.1: Bu₃SnH; AIBN / benzene / 1 h / Heating

4.1: 87 percent / NaBH₄ / methanol / 2 h

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; tri-n-butyl-tin hydride; In methanol; dichloromethane; benzene;
DOI:10.3987/com-02-s(m)42

Reference yield:

: 503822-32-0
(R)-2-(but-2-enylamino)-2-phenylethanol

: 503822-44-4
(1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / 2 h / Heating

2: Bu₃SnH; AIBN / benzene / 1 h / Heating

3: 87 percent / NaBH₄ / methanol / 2 h

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; benzene;
DOI:10.3987/com-02-s(m)42