(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate
CAS No.:1314081-71-4
Molecular Formula:C₂₁H₂₃ClN₂O₄S
Molecular Weight:434.944
Hs Code.:

Synonyms:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

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Chemical Property of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

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Technology Process of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

There total 5 articles about (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 1147350-75-1,109904-27-0
2-Oxoclopidogrel

: 1314081-71-4
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

Guidance literature:: 2-Oxoclopidogrel; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

1-pyrrolidinecarbonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; for 2h;
DOI:10.1021/jm300038c

Reference yield: 46.0%

: 1314081-71-4
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Cooling with ice;

at 0 - 20 ℃; for 3h;

Reference yield:

: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

: 1314081-71-4
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 25 °C

With sodium hydride; potassium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm300038c