6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide

Base Information

• Chemical Name: 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide
• CAS No.: 1367124-88-6
• Molecular Formula: C₂₄H₂₅FN₄O₃
• Molecular Weight: 436.486
• Mol file: 1367124-88-6.mol

Synonyms:6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide

Chemical Property of 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide

There total 8 articles about 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H23FN4O2 (1367126-66-6) → 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide (1367124-88-6)

Guidance literature:

With water; PtH(PMe₂O)2(PMe₂(OH)); In ethanol; Microwave irradiation; Heating;

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide (1367124-88-6)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4: potassium phosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane / 160 °C / Inert atmosphere; Microwave irradiation

5: water / PtH(PMe₂O)2(PMe₂(OH)) / ethanol / Microwave irradiation; Heating

With potassium phosphate; dimethylaminoacetic acid; water; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium diacetate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide (1367124-88-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 6 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4.1: potassium phosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane / 160 °C / Inert atmosphere; Microwave irradiation

5.1: water / PtH(PMe₂O)2(PMe₂(OH)) / ethanol / Microwave irradiation; Heating

With potassium phosphate; water; dihydrogen peroxide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; methyltrioxorhenium(VII); In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-Cyanopyridine

1-Bromo-4-fluorobenzene

4-Fluorophenol

1-bromo-4-(4-fluorophenoxy) benzene