2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Base Information

Chemical Name:2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester
CAS No.:911857-27-7
Molecular Formula:C₁₉H₂₄N₆O₅
Molecular Weight:416.437
Hs Code.:

Synonyms:2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

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Chemical Property of 2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

There total 4 articles about 2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3,5-dimethyl-4-oxo-[1,3,5]triazinane-1-carboxamide trifluoroacetate salt

: 141-97-9
ethyl acetoacetate

: 555-16-8
4-nitrobenzaldehdye

: 911857-27-7
2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;
DOI:10.1021/jo061199m

Reference yield:

: 911857-60-8
5-benzyl-1,3-dimethyl-[1,3,5]triazinan-2-one

: 911857-27-7
2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / Pd/C / ethanol / 18 h / 65 °C / 38786.1 Torr

2: 53 percent / tetrahydrofuran / 24 h / 70 °C

3: 100 percent / CH₂Cl₂ / 1 h / 20 °C

4: 86 percent / NaHCO₃ / dimethylformamide / 12 h / 70 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 4: Biginelli reaction;
DOI:10.1021/jo061199m

Reference yield:

: 96591-16-1
1,3-dimethyl-[1,3,5]triazinan-2-one

: 911857-27-7
2-(3,5-dimethyl-4-oxo-[1,3,5]triazin-1-yl)-6-methyl-4-(4-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / tetrahydrofuran / 24 h / 70 °C

2: 100 percent / CH₂Cl₂ / 1 h / 20 °C

3: 86 percent / NaHCO₃ / dimethylformamide / 12 h / 70 °C

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Biginelli reaction;
DOI:10.1021/jo061199m