toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester
• CAS No.: 1114971-04-8
• Molecular Formula: C₁₇H₁₅NO₃S
• Molecular Weight: 313.377
• Mol file: 1114971-04-8.mol

Synonyms:toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester

Chemical Property of toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester

There total 1 articles about toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

4-hydroxy-2-methylquinoline (607-67-0) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester (1114971-04-8)

Guidance literature:

With copper(l) iodide; caesium carbonate; In water; acetone; at 20 ℃; for 0.666667h;

DOI:10.1002/jhet.3202

Reference yield: 92.0%

toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester (1114971-04-8) + C12H15ClOZn*ClLi → 1-[3-(2-methylquinolin-4-ylmethyl)phenyl]pentan-1-one (1048028-30-3)

Guidance literature:

With bis(acetylacetonate)nickel(II); triphenylphosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b803072c

Reference yield: 70.0%

toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester (1114971-04-8) + p-trifluoromethylphenyl bromide (402-43-7) → 2-methyl-4-(4-(trifluoromethyl)phenyl)quinoline (180781-20-8)

Guidance literature:

p-trifluoromethylphenyl bromide; With chloro-trimethyl-silane; boric acid tributyl ester; magnesium; ethylene dibromide; lithium chloride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

toluene-4-sulfonic acid 2-methyl-quinolin-4-yl ester; With 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; palladium dichloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; at 65 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201103022

upstream raw materials:

4-hydroxy-2-methylquinoline

p-toluenesulfonyl chloride

Downstream raw materials:

1-[3-(2-methylquinolin-4-ylmethyl)phenyl]pentan-1-one

2-methyl-4-(4-(trifluoromethyl)phenyl)quinoline